Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 15/20 | 0.78 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.76 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.76 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.76 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.76 |
| ▸ | SCD | O00767 | 1/20 | 0.62 |
| ▸ | MMP13 | P45452 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18289707 | 0.86 | ACP1 (1.00) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL18289819 | 0.84 | ACP1 (0.82) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL4919533 | 0.77 | SCD (1.00) | SCDMMP13MAPTKMT2AALDH1A1 | |
| SCHEMBL20281592 | 0.77 | ACP1 (0.75) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL18289896 | 0.76 | ACP1 (0.77) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL18289821 | 0.76 | ACP1 (0.71) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL18289826 | 0.76 | ACP1 (0.71) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL4917926 | 0.74 | CSNK1D (0.73) | ACP1SCDMMP13MAPTKMT2A | |
| SCHEMBL594516 | 0.74 | SCD (0.69) | SCDMMP13MAPTKMT2AALDH1A1 | |
| SCHEMBL18289902 | 0.74 | ACP1 (0.77) | ACP1PTPN7PTPN12PTPN13SSU72 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| WO-2016196569-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016196591-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | PTPA, EPM2A, PTPRA | ACP1 66/4885PTPN7 48/4885PTPN12 53/4885 |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | PTPA, PTPRA, PTPRCAP | ACP1 75/4885PTPN7 32/4885PTPN12 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.