Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 13/20 | 0.71 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.71 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.71 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.71 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.71 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18289821 | 0.86 | ACP1 (0.71) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL18289707 | 0.83 | ACP1 (1.00) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL18289819 | 0.79 | ACP1 (0.82) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL18289823 | 0.76 | ACP1 (0.65) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL18289801 | 0.76 | ACP1 (0.78) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL18289892 | 0.75 | ACP1 (1.00) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL11421487 | 0.74 | RAB9A (0.77) | ACP1CSNK1DRAB9ANPC1MEN1 | |
| SCHEMBL30553310 | 0.73 | NPC1 (0.74) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL9036463 | 0.73 | NPC1 (0.74) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL4918642 | 0.72 | HTT (0.76) | RAB9ANPC1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| WO-2016196591-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016196569-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | PTPA, EPM2A, PTPRA | ACP1 66/4885PTPN7 48/4885PTPN12 53/4885 |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | PTPA, PTPRA, PTPRCAP | ACP1 75/4885PTPN7 32/4885PTPN12 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.