Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 1/20 | 0.47 |
| ▸ | SOD1 | P00441 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | BCL9 | O00512 | 3/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 2/20 | 0.36 |
| ▸ | FDPS | P14324 | 2/20 | 0.36 |
| ▸ | PNLIP | P16233 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18290299 | 0.84 | KARS1 (0.48) | KARS1SOD1BCL9CTNNB1CYP3A4 | |
| SCHEMBL16006712 | 0.84 | KARS1 (0.48) | KARS1SOD1BCL9CTNNB1CYP3A4 | |
| SCHEMBL17388698 | 0.84 | KARS1 (0.48) | KARS1SOD1BCL9CTNNB1CYP3A4 | |
| SCHEMBL18290217 | 0.73 | KARS1 (0.47) | KARS1SOD1BCL9CTNNB1CYP3A4 | |
| SCHEMBL18290297 | 0.73 | KARS1 (0.47) | KARS1SOD1BCL9CTNNB1CYP3A4 | |
| Sugiol SCHEMBL17407685 | 0.66 | SOD1 (0.58) | KARS1SOD1CYP3A4MAPTMEN1 | |
| Hypargenin C SCHEMBL13532268 | 0.66 | SOD1 (0.55) | KARS1SOD1BCL9CTNNB1CYP3A4 | |
| Hypargenin C SCHEMBL31083234 | 0.66 | SOD1 (0.55) | KARS1SOD1BCL9CTNNB1CYP3A4 | |
| Hypargenin C SCHEMBL18290364 | 0.66 | SOD1 (0.55) | KARS1SOD1BCL9CTNNB1CYP3A4 | |
| Sugiol SCHEMBL28605319 | 0.66 | SOD1 (0.58) | KARS1SOD1CYP3A4MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192631-A1 | ABIETANE-TYPE DITERPENE COMPOUND HAVING LIPID-LOWERING ACTIVITY, METHOD FOR PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |