Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291650 | 0.91 | ALDH1A1 (0.54) | HRH3ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL18291450 | 0.87 | ALDH1A1 (0.50) | HRH3ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL20038314 | 0.83 | KMT2A (0.46) | HRH3ALDH1A1KMT2AMEN1ATM | |
| SCHEMBL18291580 | 0.83 | ALDH1A1 (0.45) | HRH3ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL14308131 | 0.83 | LMNA (0.54) | HRH3ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL20255572 | 0.82 | HRH3 (0.48) | HRH3ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL18291395 | 0.82 | HRH3 (0.43) | HRH3ALDH1A1KMT2AMEN1ATM | |
| SCHEMBL20038580 | 0.82 | HRH3 (0.43) | HRH3ALDH1A1KMT2AMEN1ATM | |
| SCHEMBL20249482 | 0.82 | HRH3 (0.45) | HRH3ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL18291585 | 0.80 | KMT2A (0.48) | ALDH1A1KMT2AMEN1ATMACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016194831-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | 帝人ファーマ株式会社 | 2016-12-08 | — | — | WO | disclosed |