SCHEMBL18291334

SCHEMBL18291334

Nc1ccc(N2CC3(CCC3)C2)cn1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.37
CHRNA4 P43681 2/20 0.37
TSHR P16473 4/20 0.35
CYP3A4 P08684 8/20 0.35
ALDH1A1 P00352 5/20 0.35
USP2 O75604 4/20 0.35
CYP1A2 P05177 4/20 0.35
HSD17B10 Q99714 4/20 0.35
CYP2D6 P10635 3/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
MAPK1 P28482 2/20 0.35
TP53 P04637 1/20 0.35
HPGD P15428 1/20 0.35
PIK3CA P42336 1/20 0.34
MTOR P42345 1/20 0.34
NOS3 P29474 1/20 0.34
NOS2 P35228 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CYP2C9 P11712 8/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20037703 0.85 TSHR (0.54) CHRNB2CHRNA4TSHRCYP3A4ALDH1A1
SCHEMBL30316071 0.85 PIK3CA (0.42) CHRNB2CHRNA4TSHRCYP3A4ALDH1A1
SCHEMBL24746056 0.85 PIK3CA (0.42) CHRNB2CHRNA4TSHRCYP3A4ALDH1A1
SCHEMBL17055150 0.81 CHRNB2 (0.42) CHRNB2CHRNA4TSHRCYP3A4ALDH1A1
SCHEMBL17054926 0.81 ACVR1 (0.37) CHRNB2CHRNA4ALDH1A1PIK3CAMTOR
SCHEMBL17055000 0.81 HDAC4 (0.39) CHRNB2CHRNA4PIK3CAMTORNOS3
SCHEMBL18291361 0.81 CDK4 (0.40) CHRNB2CHRNA4TSHRCYP3A4ALDH1A1
SCHEMBL17796825 0.81 FFAR2 (0.41) CHRNB2CHRNA4TSHRCYP3A4ALDH1A1
SCHEMBL18291277 0.80 TSHR (0.44) CHRNB2CHRNA4TSHRCYP3A4ALDH1A1
SCHEMBL31330289 0.79 CHRNB2 (0.38) CHRNB2CHRNA4SMN1; SMN2PIK3CAMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016194831-A1 PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF 帝人ファーマ株式会社 2016-12-08 WO disclosed