Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291608 | 0.85 | PDE1B (0.44) | PDE1BJAK2JAK1GRM2GABRA1 | |
| SCHEMBL20037928 | 0.85 | PDE1B (0.46) | PDE1BJAK2JAK1GRM2LCK | |
| SCHEMBL20037606 | 0.84 | PDE1B (0.46) | PDE1BJAK2JAK1GRM2LCK | |
| SCHEMBL20249170 | 0.83 | PDE1B (0.43) | PDE1BJAK2JAK1GRM2NAMPT | |
| SCHEMBL392141 | 0.76 | HRH3 (0.56) | — | |
| SCHEMBL6132960 | 0.76 | JAK2 (0.44) | PDE1BJAK2JAK1GRM2GAA | |
| SCHEMBL23106917 | 0.75 | FLT3 (0.43) | PRMT5WDR77GABRA1GABRA5CHRM1 | |
| SCHEMBL18291378 | 0.71 | HRH3 (0.53) | PDE1B | |
| SCHEMBL27083845 | 0.71 | LIPG (0.47) | PDE1BJAK2JAK1GRM2 | |
| SCHEMBL18291445 | 0.71 | PRMT5 (0.39) | VNN1PRMT5WDR77GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016194831-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | 帝人ファーマ株式会社 | 2016-12-08 | — | — | WO | disclosed |