Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 12/20 | 0.41 |
| ▸ | PGR | P06401 | 6/20 | 0.41 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1316150 | 0.91 | MAPT (0.49) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL1780352 | 0.90 | MAPT (0.41) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL17667957 | 0.90 | MAPT (0.45) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL1313918 | 0.88 | MAPT (0.42) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL1314233 | 0.88 | LMNA (0.62) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL1780365 | 0.86 | MAPT (0.41) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL1313997 | 0.86 | MAPT (0.46) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL1315415 | 0.86 | NR3C1 (0.42) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL1779120 | 0.86 | LMNA (0.44) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL17667946 | 0.85 | MAPT (0.46) | MAPTLMNAHTTNPSR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2319835-A1 | GLUCOCORTICOID RECEPTOR AGONIST COMPOSED OF 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED OXY GROUP | Santen Pharmaceutical Co., Ltd (JP) | 2011-05-11 | — | — | EP | claimed |
| EP-2319835-B1 | GLUCOCORTICOID RECEPTOR AGONIST COMPOSED OF 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED OXY GROUP | AYUMI PHARMACEUTICAL CORP (JP) | 2016-04-13 | — | — | EP | disclosed |
| EP-2319835-A1 | GLUCOCORTICOID RECEPTOR AGONIST COMPOSED OF 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED OXY GROUP | Santen Pharmaceutical Co., Ltd (JP) | 2011-05-11 | — | — | EP | disclosed |