SCHEMBL1829366

SCHEMBL1829366

Cc1cccc(N2CCC(C)C2=O)c1

nearest known ligand 0.57

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 2/20 0.53
KMT2A Q03164 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.46
ALOX5 P09917 3/20 0.45
HSP90AA1 P07900 1/20 0.45
MGLL Q99685 1/20 0.45
NOTUM Q6P988 1/20 0.44
DRD2 P14416 1/20 0.44
DRD3 P35462 1/20 0.44
ALDH1A1 P00352 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1829503 0.91 KMT2A (0.52) HSD11B1KMT2AL3MBTL1MAOAMAOB
SCHEMBL19339952 0.83 NPSR1 (0.43) HSD11B1KMT2AHSP90AA1
SCHEMBL12099243 0.83 HSD11B1 (0.52) HSD11B1KMT2AL3MBTL1MAOAMAOB
SCHEMBL14275593 0.83 HSD11B1 (0.52) HSD11B1KMT2AL3MBTL1MAOAMAOB
SCHEMBL266004 0.81 MEN1 (0.50) KMT2AL3MBTL1ALDH1A1
SCHEMBL12015718 0.81 MEN1 (0.50) KMT2AL3MBTL1ALDH1A1
SCHEMBL25078426 0.80 HSD11B1 (0.47) HSD11B1KMT2AL3MBTL1MAOAMAOB
SCHEMBL12528001 0.80 HTT (0.48) KMT2AALOX5DRD2DRD3ALDH1A1
SCHEMBL17324576 0.79 ROCK2 (0.51) HSD11B1KMT2AL3MBTL1MAOAMAOB
SCHEMBL892811 0.79 NOTUM (0.53) HSD11B1KMT2AL3MBTL1MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5248736-A Reacting end groups of conjugated diene polymer with carbon dioxide or carbon disulfide and then with pyrrolidone NIPPON ZEON CO., LTD. (JP) 1993-09-28 US claimed
US-10072138-B2 Rubber composition for use in tire treads THE YOKOHAMA RUBBER CO., LTD (JP) 2018-09-11 US disclosed
US-9567451-B2 Rubber composition for use in tire treads THE YOKOHAMA RUBBER CO., LTD. (JP) 2017-02-14 US disclosed
US-9493638-B2 Rubber composition for tire THE YOKOHAMA RUBBER CO., LTD. (JP) 2016-11-15 US disclosed
US-9493629-B2 Modified butadiene-based polymer composition ASAHI KASEI CHEMICALS CORPORATION (JP) 2016-11-15 US disclosed
US-9475924-B2 Rubber composition for tire tread and pneumatic tire using the same THE YOKOHAMA RUBBER CO., LTD. (JP) 2016-10-25 US disclosed
US-9416252-B2 Rubber composition for tire tread THE YOKOHAMA RUBBER CO., LTD. (JP) 2016-08-16 US disclosed
US-9139721-B2 Rubber composition for tire treads THE YOKOHAMA RUBBER CO., LTD. (JP) 2015-09-22 US disclosed
US-20150126643-A1 Rubber Composition for Tire THE YOKOHAMA RUBBER CO., LTD. (JP) 2015-05-07 US disclosed
US-20150031791-A1 Rubber Composition for Tire Treads THE YOKOHAMA RUBBER CO., LTD. (JP) 2015-01-29 US disclosed
US-5281671-A End-modified butadiene polymer and diene rubber other than the end-modified butadiene, the end modifier being an N-substituted aminoketone, thioaminoketone, aminoaldehyde, or thioaminoaldehyde NIPPON ZEON CO., LTD. (JP) 1994-01-25 US disclosed
US-5248736-A Reacting end groups of conjugated diene polymer with carbon dioxide or carbon disulfide and then with pyrrolidone NIPPON ZEON CO., LTD. (JP) 1993-09-28 US disclosed
US-5219942-A Blend of end-modified styrene-butadiene copolymer and diene rubber NIPPON ZEON CO., LTD. (JP) 1993-06-15 US disclosed
US-5217839-A Dispersion containing mixture of a polymer with a carbon nitrogen double bond and a colorant in a vinyl monomer NIPPON ZEON CO., LTD. (JP) 1993-06-08 US disclosed
US-5218023-A Anionic polymers NIPPON ZEON CO., LTD. (JP) 1993-06-08 US disclosed
US-5216080-A Butadiene-styrene copolymers endcapped with N-modified amino ketones, thioamino ketones, thioamino aldehydes, lactams, thiolactams, ethyleneurea and thioethylene urea; wear resistant, large-sized tires NIPPON ZEON CO., LTD. (JP) 1993-06-01 US disclosed
EP-0438248-A2 Preparation process of toner NIPPON ZEON CO., LTD. (JP) 1991-07-24 EP disclosed
EP-0435544-A2 Abrasion-resistant rubber compositions NIPPON ZEON CO., LTD. (JP) 1991-07-03 EP disclosed
EP-0434353-A2 Rubber compositions NIPPON ZEON CO., LTD. (JP) 1991-06-26 EP disclosed
EP-0382205-A2 Additive for thermosetting resins and thermosetting resin composition containing additive NIPPON ZEON CO., LTD. (JP) 1990-08-16 EP disclosed