Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 17/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20185314 | 0.77 | PDE2A (0.49) | PDE2A | |
| SCHEMBL18283132 | 0.76 | PDE2A (0.51) | PDE2A | |
| SCHEMBL22475495 | 0.72 | PDE2A (0.68) | PDE2A | |
| SCHEMBL22475582 | 0.67 | PDE2A (0.47) | PDE2A | |
| SCHEMBL22422954 | 0.65 | CDK4 (0.50) | PDE2A | |
| SCHEMBL18283097 | 0.65 | PDE2A (0.52) | PDE2A | |
| SCHEMBL24208439 | 0.65 | P2RY14 (0.48) | HTR2CHTR2B | |
| SCHEMBL22422993 | 0.64 | CDK4 (0.45) | PDE2AHTR2CHTR2B | |
| SCHEMBL20185144 | 0.64 | PDE2A (0.44) | PDE2A | |
| SCHEMBL5906079 | 0.64 | HTR2C (0.46) | HTR2CHTR2BDAONPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196071-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |