Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 19/20 | 0.68 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18283132 | 0.85 | PDE2A (0.51) | PDE2A | |
| SCHEMBL20185314 | 0.83 | PDE2A (0.49) | PDE2A | |
| SCHEMBL20185302 | 0.81 | PDE2A (1.00) | PDE2A | |
| SCHEMBL20185301 | 0.81 | PDE2A (1.00) | PDE2A | |
| SCHEMBL22475582 | 0.78 | PDE2A (0.47) | PDE2A | |
| SCHEMBL22422954 | 0.75 | CDK4 (0.50) | PDE2A | |
| SCHEMBL22423073 | 0.74 | PDE2A (0.52) | PDE2A | |
| SCHEMBL18291868 | 0.73 | CDK4 (0.52) | PDE2A | |
| SCHEMBL18294941 | 0.72 | PDE2A (0.49) | PDE2A | |
| SCHEMBL22422993 | 0.72 | CDK4 (0.45) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3302486-B1 | DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-09-30 | — | — | EP | disclosed |