Betamethasone Dipropionate

SCHEMBL18301225

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C.CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 0.93

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Betamethasone Dipropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	7/20	0.93

▸	PGR	P06401	6/20	0.93

▸	ADORA3	P0DMS8	3/20	0.93

▸	NR1I2	O75469	2/20	0.93

▸	MAPT	P10636	2/20	0.93

▸	DRD2	P14416	1/20	0.93

▸	OPRD1	P41143	1/20	0.93

▸	CYP3A4	P08684	5/20	0.91

▸	USP2	O75604	5/20	0.91

▸	LMNA	P02545	2/20	0.91

▸	MLNR	O43193	1/20	0.91

▸	ABCB11	O95342	1/20	0.91

▸	CYP3A5	P20815	1/20	0.91

▸	PPARG	P37231	1/20	0.91

▸	SMN1; SMN2	Q16637	1/20	0.91

▸	NPSR1	Q6W5P4	1/20	0.91

▸	CYP2D6	P10635	1/20	0.91

▸	CYP2C9	P11712	1/20	0.91

▸	AR	P10275	2/20	0.77

▸	CHRM1	P11229	2/20	0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Betamethasone Dipropionate SCHEMBL7519	0.96	NR3C1 (1.00)	NR3C1PGRADORA3NR1I2MAPT
Betamethasone Dipropionate SCHEMBL10014288	0.96	NR3C1 (1.00)	NR3C1PGRADORA3NR1I2MAPT
Betamethasone Dipropionate SCHEMBL9768468	0.96	NR3C1 (1.00)	NR3C1PGRADORA3NR1I2MAPT
Dexamethasone Dipropionate SCHEMBL43107	0.96	NR3C1 (1.00)	NR3C1PGRADORA3NR1I2MAPT
Betamethasone Dipropionate SCHEMBL20097870	0.96	NR3C1 (1.00)	NR3C1PGRADORA3NR1I2MAPT
Betamethasone Dipropionate SCHEMBL13028946	0.96	NR3C1 (1.00)	NR3C1PGRADORA3NR1I2MAPT
Betamethasone Dipropionate SCHEMBL10013893	0.96	NR3C1 (1.00)	NR3C1PGRADORA3NR1I2MAPT
Betamethasone Dipropionate SCHEMBL11429865	0.96	NR3C1 (1.00)	NR3C1PGRADORA3NR1I2MAPT
Betamethasone Dipropionate SCHEMBL4566	0.96	NR3C1 (1.00)	NR3C1PGRADORA3NR1I2MAPT
Betamethasone Dipropionate SCHEMBL14339597	0.96	NR3C1 (1.00)	NR3C1PGRADORA3NR1I2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2016198998-A1	A MEDICINAL CREAM MADE USING CLOBETASOL PROPIONATE AND INCORPORATING A BIOPOLYMER AND A PROCESS TO MAKE IT	SULUR SUBRAMANIAM VANANGAMUDI (IN)	2016-12-15	—	—	WO	disclosed