2-Oxoisohexanoate

2-Oxoisohexanoate

SCHEMBL18302256

CC(C)CC(=O)C(=O)O.CC(C)CC(=O)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.52
ALDH1A1 P00352 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
OR51E2 Q9H255 2/20 0.40
MMP1 P03956 1/20 0.39
MMP2 P08253 1/20 0.39
MMP3 P08254 1/20 0.39
MMP9 P14780 1/20 0.39
MMP13 P45452 1/20 0.39
CA1 P00915 2/20 0.38
CYP2C19 P33261 2/20 0.38
CYP2D6 P10635 1/20 0.38
MAPK1 P28482 1/20 0.36
SLC13A3 Q8WWT9 1/20 0.36
EGLN1 Q9GZT9 1/20 0.36
RNPEP Q9H4A4 1/20 0.36
SLC7A5 Q01650 1/20 0.36
CACNB3 P54284 1/20 0.36
CACNA2D1 P54289 1/20 0.36
CACNA1C Q13936 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Oxoisohexanoate SCHEMBL43491 1.00
2-Oxoisohexanoate SCHEMBL6845538 0.97 CA2 (0.50) CA2ALDH1A1TDP1OR51E2MMP1
2-Oxoisohexanoate SCHEMBL2224962 0.97 CA2 (0.50) CA2ALDH1A1TDP1OR51E2MMP1
2-Oxoisohexanoate SCHEMBL4364799 0.97 CA2 (0.50) CA2ALDH1A1TDP1OR51E2MMP1
2-Oxoisohexanoate SCHEMBL7278860 0.97 CA2 (0.50) CA2ALDH1A1TDP1OR51E2MMP1
2-Oxoisohexanoate SCHEMBL5160502 0.94 CA2 (0.48) CA2ALDH1A1TDP1OR51E2MMP1
2-Oxoisohexanoate SCHEMBL28052970 0.92 ALDH1A1 (0.50) CA2ALDH1A1TDP1OR51E2MMP1
2-Oxoisohexanoate SCHEMBL31717986 0.89 CA2 (0.44) CA2ALDH1A1TDP1OR51E2MMP1
2-Oxoisohexanoate SCHEMBL5606890 0.87 SLC7A5 (0.44) CA2ALDH1A1TDP1MMP1MMP2
2-Oxoisohexanoate SCHEMBL5606991 0.87 OR51E2 (0.48) CA2ALDH1A1TDP1OR51E2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024242409-A1 MUTANT POLYPEPTIDE AND METHOD FOR PRODUCING L-VALINE USING SAME 씨제이제일제당 (주) 2024-11-28 WO disclosed
CN-114569633-B Intestinal selective chelators for the treatment and prevention of autism and related disorders 轴向治疗公司 2023-11-17 CN disclosed
CN-114569633-A Gut-selective chelating agents for the treatment and prevention of autism and related disorders 轴向治疗公司 2022-06-03 CN disclosed
EP-3986432-A1 OPTIMIZED BACTERIA ENGINEERED TO TREAT DISORDERS INVOLVING THE CATABOLISM OF LEUCINE, ISOLEUCINE, AND/OR VALINE Synlogic Operating Company, Inc. (US) 2022-04-27 EP disclosed
EP-3388524-B1 ENZYMATIC METHOD FOR PRODUCING 2-HYDROXY-4-METHYLMERCAPTOBUTANOIC ACID (MHA) EVONIK OPERATIONS GMBH (DE) 2022-03-16 EP disclosed
CN-110944650-B Gut-selective chelating agents for the treatment and prevention of autism and related disorders 轴向治疗公司 2022-03-04 CN disclosed
CN-114085800-A Novel isopropylmalate synthase variants and method for producing L-leucine using same CJ第一制糖株式会社 2022-02-25 CN disclosed
CN-108884449-B Novel isopropylmalate synthase variants and method for producing L-leucine using same CJ第一制糖株式会社 2022-01-25 CN disclosed
WO-2020257610-A1 OPTIMIZED BACTERIA ENGINEERED TO TREAT DISORDERS INVOLVING THE CATABOLISM OF LEUCINE, ISOLEUCINE, AND/OR VALINE SYNLOGIC OPERATING COMPANY, INC. (US) 2020-12-24 WO disclosed
EP-3307870-A1 BACTERIA ENGINEERED TO TREAT DISORDERS INVOLVING THE CATABOLISM OF A BRANCHED CHAIN AMINO ACID Synlogic, Inc. (US) 2018-04-18 EP disclosed
WO-2016201380-A9 BACTERIA ENGINEERED TO TREAT DISORDERS INVOLVING THE CATABOLISM OF A BRANCHED CHAIN AMINO ACID SYNLOGIC, INC. (US) 2017-02-16 WO disclosed
WO-2016201380-A1 BACTERIA ENGINEERED TO TREAT DISORDERS INVOLVING THE CATABOLISM OF A BRANCHED CHAIN AMINO ACID SYNLOGIC, INC. (US) 2016-12-15 WO disclosed