Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.71 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.71 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.74 |
| ▸ | BLM | P54132 | 3/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.71 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.71 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.71 |
| ▸ | DRD1 | P21728 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 2/20 | 0.71 |
| ▸ | HTR1A | P08908 | 2/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylephrine SCHEMBL5665418 | 0.99 | HIF1A (0.73) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL1832329 | 0.93 | HIF1A (0.64) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL30104947 | 0.86 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL24655 | 0.86 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL29382859 | 0.86 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL5053821 | 0.86 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL30800718 | 0.86 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL412215 | 0.86 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL21829033 | 0.86 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL24654 | 0.86 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307280-B1 | TREATMENT OF SEXUAL DYSFUNCTION | ReJoy (US) | 2021-10-27 | — | — | EP | disclosed |
| US-10357452-B2 | Treatment of sexual dysfunction | ReJoy (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180296471-A1 | TREATMENT OF SEXUAL DYSFUNCTION | ReJoy (US) | 2018-10-18 | — | — | US | disclosed |
| US-10064816-B2 | Treatment of sexual dysfunction | ReJoy (US) | 2018-09-04 | — | — | US | disclosed |
| EP-3307280-A1 | TREATMENT OF SEXUAL DYSFUNCTION | Rejoy (US) | 2018-04-18 | — | — | EP | disclosed |
| US-20180078499-A1 | TREATMENT OF SEXUAL DYSFUNCTION | ReJoy (US) | 2018-03-22 | — | — | US | disclosed |
| US-20170165253-A1 | TREATMENT OF SEXUAL DYSFUNCTION AND FOR IMPROVED SEXUAL QUALITY OF LIFE | ReJoy (US) | 2017-06-15 | — | — | US | disclosed |
| WO-2016201286-A1 | TREATMENT OF SEXUAL DYSFUNCTION | APPLIED BIOLOGY, INC. (US) | 2016-12-15 | — | — | WO | disclosed |