Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.64 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.64 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylephrine SCHEMBL5665418 | 0.94 | HIF1A (0.73) | HIF1AADRA1AADRA2CADRB1TSHR | |
| Phenylephrine SCHEMBL18305612 | 0.93 | HIF1A (0.74) | HIF1AADRA1AADRA2CADRB1TSHR | |
| Ephedrine SCHEMBL21980908 | 0.89 | ADRA1A (0.71) | HIF1AADRA1AADRA2CADRB1TSHR | |
| Oxedrine SCHEMBL6137715 | 0.81 | HIF1A (0.66) | HIF1AADRA1AADRA2CADRB1TSHR | |
| Ephedrine SCHEMBL9641985 | 0.80 | ADRA2C (0.81) | HIF1AADRA1AADRA2CADRB1TSHR | |
| Pseudoephedrine SCHEMBL282453 | 0.80 | ADRA2C (0.81) | HIF1AADRA1AADRA2CADRB1TSHR | |
| Pseudoephedrine SCHEMBL4780816 | 0.80 | ADRA2C (0.81) | HIF1AADRA1AADRA2CADRB1TSHR | |
| Phenylephrine SCHEMBL895602 | 0.80 | HIF1A (1.00) | HIF1AADRA1AADRA2CADRB1TSHR | |
| Phenylephrine SCHEMBL4711 | 0.80 | HIF1A (1.00) | HIF1AADRA1AADRA2CADRB1TSHR | |
| Phenylephrine SCHEMBL29382851 | 0.80 | HIF1A (1.00) | HIF1AADRA1AADRA2CADRB1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140234410-A1 | COMBINATION PRODUCTS | SIGMOID PHARMA LTD. (IE) | 2014-08-21 | — | — | US | disclosed |
| EP-2322146-B1 | Microcapsule formulations comprising two pharmaceutically active ingredients | SIGMOID PHARMA LTD (IE) | 2012-12-12 | — | — | EP | disclosed |
| EP-2444071-A1 | Minicapsule formulations | Sigmoid Pharma Limited (IE) | 2012-04-25 | — | — | EP | disclosed |
| EP-2322146-A2 | Microcapsule formulations comprising two pharmaceutically active ingredients | Sigmoid Pharma Limited (IE) | 2011-05-18 | — | — | EP | disclosed |
| EP-2156826-A1 | Microcapsule formulations comprising two pharmaceutically active ingredients | Sigmoid Pharma Limited (IE) | 2010-02-24 | — | — | EP | disclosed |
| EP-2153824-A1 | Seamless multiparticulate formulations | Sigmoid Pharma Limited (IE) | 2010-02-17 | — | — | EP | disclosed |
| US-20080113031-A1 | seamless capsules having cores containing drugs, to enhance bioavailability, sustained release or time release of drugs | SIGMOID PHARMA LIMITED (IE) | 2008-05-15 | — | — | US | disclosed |
| US-20080020018-A1 | Combination Products | SIGMOID PHARMA LIMITED (IE) | 2008-01-24 | — | — | US | disclosed |
| EP-1811979-A2 | MICROCAPSULES COMPRISING A METHYLXANTHINE AND A CORTICOSTEROID | Sigmoid Biotechnologies Limited (IE) | 2007-08-01 | — | — | EP | disclosed |
| EP-1499303-A4 | MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM | MILLER FRED H (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1802287-A2 | MINICAPSULE FORMULATIONS | Sigmoid Biotechnologies Limited (IE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006035418-A2 | MICROCAPSULES COMPRISING A METHYLXANTHINE AND A CORTICOSTEROID | SIGMOID BIOTECHNOLOGIES LIMITED (IE) | 2006-04-06 | — | — | WO | disclosed |
| WO-2006035416-A2 | MINICAPSULE FORMULATIONS | SIGMOID BIOTECHNOLOGIES LIMITED (IE) | 2006-04-06 | — | — | WO | disclosed |
| EP-1499303-A2 | MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM | Miller, Fred H. (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086267-A2 | MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM | MILLER FRED H (US) | 2003-10-23 | — | — | WO | disclosed |