SCHEMBL18306418

SCHEMBL18306418

O=C(O)C(=Cc1cccc(Cl)c1O)C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.39
KDM4E B2RXH2 2/20 0.39
DPP4 P27487 1/20 0.38
CD38 P28907 1/20 0.38
TSHR P16473 2/20 0.38
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 1/20 0.38
KMT2A Q03164 1/20 0.38
HSD17B10 Q99714 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
AKR1B1 P15121 1/20 0.37
FEN1 P39748 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7311482 0.82 TRPA1 (0.50) TP53MEN1ALDH1A1KMT2A
SCHEMBL8669956 0.81 ERN1 (0.55) TP53KDM4EALDH1A1HSD17B10
SCHEMBL18306419 0.78 ERN1 (0.58) TP53KDM4ECD38
SCHEMBL18306421 0.78 KDM4E (0.42) TP53KDM4EMEN1ALDH1A1KMT2A
SCHEMBL16287426 0.75 TP53 (0.56) TP53KDM4E
SCHEMBL9530709 0.75 ERN1 (0.38) KDM4ECD38TSHRMEN1ALDH1A1
SCHEMBL17040193 0.74 ERN1 (0.58) KDM4ETSHRMEN1ALDH1A1KMT2A
SCHEMBL359233 0.74 ERN1 (0.61) CD38TSHRMEN1ALDH1A1KMT2A
SCHEMBL29952063 0.74 ERN1 (0.61) CD38TSHRMEN1ALDH1A1KMT2A
SCHEMBL822890 0.74 KMT2A (0.44) KDM4ETSHRMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9518038-B2 Condensation product of theanine derivative and carboxylic acid coumarin derivative, its intermediate, preparation method and use thereof SHANDONG YINGDONG YINGHAO BIOTECHNOLOGY, INC. (CN) 2016-12-13 US disclosed