Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.54 |
| ▸ | ALOX5AP | P20292 | 14/20 | 0.41 |
| ▸ | FEN1 | P39748 | 14/20 | 0.41 |
| ▸ | NNMT | P40261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30657929 | 0.79 | GRM5 (0.54) | GRM5ALOX5APFEN1ALDH1A1GAA | |
| SCHEMBL858890 | 0.79 | GRM5 (0.54) | GRM5ALOX5APFEN1NNMTALDH1A1 | |
| SCHEMBL91447 | 0.79 | GRM5 (0.54) | GRM5ALOX5APFEN1ALDH1A1GAA | |
| SCHEMBL13114366 | 0.79 | GRM5 (0.54) | GRM5ALOX5APFEN1ALDH1A1GAA | |
| SCHEMBL12462535 | 0.79 | GRM5 (0.54) | GRM5ALOX5APFEN1NNMTALDH1A1 | |
| SCHEMBL1258214 | 0.76 | NNMT (0.55) | GRM5ALOX5APFEN1NNMTMAPT | |
| SCHEMBL14376061 | 0.76 | GRM5 (0.67) | GRM5ALOX5APFEN1ALDH1A1GAA | |
| SCHEMBL10283350 | 0.76 | NNMT (0.53) | GRM5ALOX5APFEN1NNMT | |
| SCHEMBL84582 | 0.75 | GRM5 (0.50) | GRM5ALOX5APFEN1ALDH1A1GAA | |
| SCHEMBL21603211 | 0.75 | GRM5 (0.50) | GRM5ALOX5APFEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265607-B1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | RIGEL PHARMACEUTICALS INC (US) | 2016-12-14 | — | — | EP | disclosed |