Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CD38 | P28907 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15540481 | 0.89 | LMNA (0.44) | LMNAHPGDPTGESAURKARPS6KB1 | |
| SCHEMBL18307324 | 0.88 | MRGPRX4 (0.46) | LMNAHPGDPTGESTSHRCNR2 | |
| SCHEMBL10046412 | 0.83 | PTGES (0.58) | PTGESTSHRCA1CA2 | |
| SCHEMBL20149736 | 0.79 | TSHR (0.50) | LMNAHPGDAURKARPS6KB1TSHR | |
| SCHEMBL30491693 | 0.76 | MRGPRX4 (0.48) | LMNAHPGDPTGESTSHRCNR2 | |
| SCHEMBL1672182 | 0.76 | MRGPRX4 (0.48) | LMNAHPGDPTGESTSHRCNR2 | |
| SCHEMBL21524574 | 0.76 | AURKA (0.40) | LMNAHPGDAURKARPS6KB1AURKB | |
| SCHEMBL16671517 | 0.75 | TSHR (0.47) | LMNAHPGDPTGESTSHRCNR2 | |
| SCHEMBL18810192 | 0.74 | PTGES (0.44) | LMNAHPGDPTGESTSHRCNR2 | |
| SCHEMBL15268110 | 0.74 | NR1H4 (0.50) | LMNAHPGDPTGESTSHRCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016199104-A1 | POLYMORPHS OF A PGES-1 INHIBITING TRIAZOLONE COMPOUND | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-12-15 | — | — | WO | disclosed |