SCHEMBL18307396

SCHEMBL18307396

OCc1cc(-c2ccccc2)n(Cc2ccccc2Cl)n1

nearest known ligand 0.64

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC16A3 O15427 20/20 0.64
SLC16A1 P53985 20/20 0.64
MCTS1 Q9ULC4 15/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18311454 0.89 SLC16A3 (0.67) SLC16A3SLC16A1MCTS1
SCHEMBL29487686 0.85 SLC16A3 (0.69) SLC16A3SLC16A1MCTS1
SCHEMBL18300792 0.85 SLC16A3 (0.69) SLC16A3SLC16A1MCTS1
SCHEMBL2225688 0.85 SLC16A3 (0.59) SLC16A3SLC16A1MCTS1
SCHEMBL31130371 0.85 SLC16A3 (0.68) SLC16A3SLC16A1MCTS1
SCHEMBL31130201 0.84 SLC16A3 (0.67) SLC16A3SLC16A1MCTS1
SCHEMBL31130395 0.83 SLC16A3 (0.69) SLC16A3SLC16A1MCTS1
SCHEMBL31130382 0.83 SLC16A3 (0.51) SLC16A3SLC16A1MCTS1
SCHEMBL31130255 0.82 SLC16A3 (0.68) SLC16A3SLC16A1MCTS1
SCHEMBL31130262 0.81 SLC16A3 (0.65) SLC16A3SLC16A1MCTS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11724989-B2 MCT4 inhibitors for treating disease Vettore, LLC (US) 2023-08-15 US disclosed
US-11724989-B2 MCT4 inhibitors for treating disease Vettore, LLC (US) 2023-08-15 US disclosed
EP-3942934-A1 MCT4 INHIBITORS FOR TREATING DISEASE Vettore, LLC (US) 2022-01-26 EP disclosed
US-11155522-B2 MCT4 inhibitors for treating disease Vettore, LLC (US) 2021-10-26 US disclosed
US-20210009524-A1 MCT4 INHIBITORS FOR TREATING DISEASE Vettore, LLC 2021-01-14 US disclosed
US-20190112274-A1 MCT4 INHIBITORS FOR TREATING DISEASE Vettore, LLC 2019-04-18 US disclosed
US-10202350-B2 MCT4 inhibitors for treating disease Vettore, LLC (US) 2019-02-12 US disclosed
US-20160362378-A1 MCT4 INHIBITORS FOR TREATING DISEASE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-12-15 US disclosed
WO-2016201426-A1 MCT4 INHIBITORS FOR TREATING DISEASE Vettore, LLC (US) 2016-12-15 WO disclosed
US-20160362378-A1 MCT4 INHIBITORS FOR TREATING DISEASE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-12-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11155522-B2 MCT4 inhibitors for treating disease SLC16A1, SLC16A3, SLC16A7 SLC16A3 2/4885SLC16A1 1/4885MCTS1 8/4885
US-10202350-B2 MCT4 inhibitors for treating disease SLC16A3, SLC16A1, MCTS1 SLC16A3 1/4885SLC16A1 2/4885MCTS1 3/4885
US-20190112274-A1 MCT4 INHIBITORS FOR TREATING DISEASE SLC16A1, SLC16A3, SLC16A7 SLC16A3 2/4885SLC16A1 1/4885MCTS1 8/4885
US-20210009524-A1 MCT4 INHIBITORS FOR TREATING DISEASE SLC16A1, SLC16A3, SLC16A7 SLC16A3 2/4885SLC16A1 1/4885MCTS1 8/4885
US-20160362378-A1 MCT4 INHIBITORS FOR TREATING DISEASE SLC16A3, SLC16A1, MCTS1 SLC16A3 1/4885SLC16A1 2/4885MCTS1 3/4885
US-11724989-B2 MCT4 inhibitors for treating disease SLC16A1, SLC16A3, SLC16A7 SLC16A3 2/4885SLC16A1 1/4885MCTS1 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.