Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | FABP2 | P12104 | 1/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954274 | 0.81 | MEN1 (0.43) | DHODHMEN1KMT2APTGS1TSHR | |
| SCHEMBL21942025 | 0.79 | TTR (0.51) | DHODHPTGS1ESR2 | |
| SCHEMBL28359829 | 0.79 | PTGS1 (0.46) | DHODHMEN1KMT2APTGS1TSHR | |
| SCHEMBL3716973 | 0.79 | PTGS1 (0.46) | DHODHMEN1KMT2APTGS1TSHR | |
| SCHEMBL11139556 | 0.79 | ESR2 (0.43) | DHODHMEN1KMT2APTGS1TSHR | |
| SCHEMBL28355967 | 0.79 | ESR2 (0.43) | DHODHMEN1KMT2APTGS1TSHR | |
| SCHEMBL9153943 | 0.79 | ESR2 (0.43) | DHODHMEN1KMT2APTGS1TSHR | |
| Hydrochloric Acid SCHEMBL28562155 | 0.77 | ESR2 (0.42) | DHODHMEN1KMT2APTGS1TSHR | |
| SCHEMBL4428961 | 0.76 | AKR1C2 (0.51) | DHODHMEN1KMT2APTGS1TSHR | |
| SCHEMBL20232735 | 0.75 | KAT6A (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307258-B1 | ARYL SULFONOHYDRAZIDES | UNIV MONASH (AU) | 2020-12-16 | — | — | EP | disclosed |
| EP-3307258-B1 | ARYL SULFONOHYDRAZIDES | UNIV MONASH (AU) | 2020-12-16 | — | — | EP | disclosed |
| US-10829446-B2 | Aryl sulfonohydrazides | MONASH UNIVERSITY (AU) | 2020-11-10 | — | — | US | disclosed |
| US-10829446-B2 | Aryl sulfonohydrazides | MONASH UNIVERSITY (AU) | 2020-11-10 | — | — | US | disclosed |
| US-20180222857-A1 | ARYL SULFONOHYDRAZIDES | MONASH UNIVERSITY (AU) | 2018-08-09 | — | — | US | disclosed |
| US-20180222857-A1 | ARYL SULFONOHYDRAZIDES | MONASH UNIVERSITY (AU) | 2018-08-09 | — | — | US | disclosed |
| WO-2016198507-A1 | ARYL SULFONOHYDRAZIDES | MONASH UNIVERSITY (AU) | 2016-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222857-A1 | ARYL SULFONOHYDRAZIDES | FPR3, NCOA3, HAT1 | DHODH 2663/4885MEN1 603/4885KMT2A 875/4885 |
| US-10829446-B2 | Aryl sulfonohydrazides | FPR3, NCOA3, HAT1 | DHODH 2663/4885MEN1 603/4885KMT2A 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.