Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16572260 | 0.88 | PDCD1 (0.47) | PDCD1CD274MEN1KMT2ACA1 | |
| SCHEMBL12808219 | 0.88 | MEN1 (0.44) | PDCD1CD274MEN1KMT2ACA1 | |
| SCHEMBL15711781 | 0.84 | PDK2 (0.40) | PDCD1CD274MEN1KMT2ACA1 | |
| SCHEMBL14124477 | 0.83 | PDCD1 (0.51) | PDCD1CD274MEN1KMT2ACA1 | |
| SCHEMBL3862588 | 0.83 | HTR7 (0.49) | APPPDCD1CD274CA1CA2 | |
| SCHEMBL31134187 | 0.83 | ERN1 (0.50) | PDCD1CD274MEN1KMT2ACA1 | |
| SCHEMBL14134329 | 0.81 | CD274 (0.40) | PDCD1CD274MEN1KMT2ACA1 | |
| SCHEMBL19888146 | 0.80 | EGFR (0.60) | MEN1KMT2ACA1CA2CA7 | |
| SCHEMBL15711835 | 0.80 | MEN1 (0.47) | PDCD1CD274MEN1KMT2ACA1 | |
| SCHEMBL17820 | 0.78 | IDO1 (0.57) | CA1CA2CA7CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737815-B1 | THIO-SUBSTITUTED BIARYL-METHANESULFINYL DERIVATIVES | CEPHALON INC (US) | 2016-12-21 | — | — | EP | disclosed |