Sugi Predict

Sugi Predict / Compounds / SCHEMBL18318797

SCHEMBL18318797

SCHEMBL18318797

CC(C)C(=O)N1CCC(Oc2ccc(-c3ccc(-c4ccccc4)nc3)cc2)CC1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ SRD5A1 P18405 1/20 0.48
▸ EPHX2 P34913 2/20 0.47
▸ NAMPT P43490 4/20 0.46
▸ ACACB O00763 1/20 0.46
▸ CYP4F2 P78329 1/20 0.44
▸ CYP4A11 Q02928 1/20 0.44
▸ HRH3 Q9Y5N1 1/20 0.43
▸ SCD5 Q86SK9 1/20 0.43
▸ ALOX15 P16050 1/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ PIK3CD O00329 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.41
▸ KDM5A P29375 1/20 0.41
▸ POLB P06746 1/20 0.41
▸ SCD O00767 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ LIPE Q05469 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18318533 0.86 MAPT (0.52) EPHX2NAMPTACACBCYP4F2CYP4A11
SCHEMBL18318748 0.85 EPHX2 (0.47) EPHX2ACACBCYP4F2CYP4A11SCD5
SCHEMBL18318131 0.85 MAP4K4 (0.53) SRD5A1EPHX2NAMPTHRH3SCD5
SCHEMBL18318617 0.84 NAMPT (0.50) EPHX2NAMPTACACBCYP4F2CYP4A11
SCHEMBL18318546 0.83 GPR119 (0.53) —
SCHEMBL18318670 0.81 PIK3CA (0.51) SRD5A1EPHX2NAMPTHRH3PIK3CD
SCHEMBL23136089 0.81 SRD5A1 (0.60) SRD5A1EPHX2NAMPTHRH3SCD5
SCHEMBL18318596 0.81 PIK3CA (0.55) SRD5A1NAMPTCYP4F2CYP4A11HRH3
Hydrochloric Acid SCHEMBL28554846 0.81 PIK3CA (0.50) SRD5A1EPHX2NAMPTHRH3PIK3CD
Trifluoroacetic Acid SCHEMBL30497912 0.80 LIPE (0.46) EPHX2ACACBCYP4F2CYP4A11PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US claimed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US claimed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN claimed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP claimed
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2018-06-28 — — US disclosed
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2018-06-28 — — US disclosed
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2018-06-28 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A SRD5A1 251/4885EPHX2 1352/4885NAMPT 491/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A SRD5A1 251/4885EPHX2 1352/4885NAMPT 491/4885
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A SRD5A1 251/4885EPHX2 1352/4885NAMPT 491/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A SRD5A1 251/4885EPHX2 1352/4885NAMPT 491/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A SRD5A1 251/4885EPHX2 1352/4885NAMPT 491/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A SRD5A1 251/4885EPHX2 1352/4885NAMPT 491/4885
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A SRD5A1 261/4885EPHX2 1374/4885NAMPT 475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.