Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24838561 | 0.98 | ALDH1A1 (0.45) | ALDH1A1EPHX2MCL1TSHRRECQL | |
| SCHEMBL22678184 | 0.90 | MCL1 (0.42) | ALDH1A1EPHX2MCL1TSHRRECQL | |
| SCHEMBL25516086 | 0.90 | MEN1 (0.46) | ALDH1A1EPHX2TSHRRECQLHSD17B10 | |
| SCHEMBL25516119 | 0.89 | ALDH1A1 (0.42) | ALDH1A1EPHX2TSHRRECQLFAAH | |
| SCHEMBL13034893 | 0.89 | ALDH1A1 (0.42) | ALDH1A1EPHX2TSHRRECQLFAAH | |
| SCHEMBL25516113 | 0.89 | ALDH1A1 (0.42) | ALDH1A1EPHX2TSHRRECQLFAAH | |
| SCHEMBL19261664 | 0.89 | ALDH1A1 (0.42) | ALDH1A1EPHX2TSHRRECQLFAAH | |
| SCHEMBL12743488 | 0.89 | ALDH1A1 (0.42) | ALDH1A1EPHX2TSHRRECQLFAAH | |
| SCHEMBL25516154 | 0.89 | ALDH1A1 (0.42) | ALDH1A1EPHX2TSHRRECQLFAAH | |
| SCHEMBL4692525 | 0.88 | MCL1 (0.47) | ALDH1A1MCL1TSHRFAAHHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988376-B2 | Benzothiophene derivatives as estrogen receptor inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-06-05 | — | — | US | disclosed |
| US-20160368911-A1 | BENZOTHIOPHENE DERIVATIVES AS ESTROGEN RECEPTOR INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368911-A1 | BENZOTHIOPHENE DERIVATIVES AS ESTROGEN RECEPTOR INHIBITORS | ESR1, GPER1, ESR2 | ALDH1A1 627/4885EPHX2 1021/4885MCL1 4406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.