Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 7/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 2/20 | 0.37 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18319705 | 0.83 | ERN1 (0.43) | ERN1BRD4TDP1BRD2ALDH1A1 | |
| SCHEMBL17875697 | 0.81 | ALDH1A1 (0.39) | ERN1BRD4TDP1BRD2MBOAT4 | |
| SCHEMBL17875696 | 0.77 | BRD4 (0.44) | BRD4BRD2MBOAT4JAK2TLR8 | |
| SCHEMBL11240092 | 0.75 | TSHR (0.39) | TDP1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL18319531 | 0.75 | ERN1 (0.38) | ERN1BRD4TDP1BRD2TLR8 | |
| SCHEMBL18319456 | 0.75 | LMNA (0.47) | BRD4BRD2ALDH1A1 | |
| SCHEMBL18319509 | 0.75 | CYP1A2 (0.36) | ERN1BRD4TDP1BRD2ALDH1A1 | |
| SCHEMBL29741402 | 0.75 | ERN1 (0.52) | ERN1BRD4TDP1BRD2JAK2 | |
| SCHEMBL20094000 | 0.75 | ERN1 (0.52) | ERN1BRD4TDP1BRD2JAK2 | |
| SCHEMBL18319709 | 0.74 | CYP1A2 (0.42) | ERN1BRD4TDP1BRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160368919-A1 | NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2016-12-22 | — | — | US | disclosed |
| US-20160368919-A1 | NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2016-12-22 | — | — | US | disclosed |
| US-20160368919-A1 | NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2016-12-22 | — | — | US | disclosed |
| WO-2016203335-A1 | NOVEL PYRIDO[2,3-B]PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2016-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368919-A1 | NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | BRD4, BRD3, BET1 | ERN1 1804/4885BRD4 1/4885TDP1 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.