Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827956 | 0.87 | NPC1 (0.47) | NPC1RAB9AL3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL1437230 | 0.77 | CNR1 (0.40) | L3MBTL1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL32662983 | 0.76 | KDM4E (0.45) | LMNASMN1; SMN2KDM4E | |
| SCHEMBL2995161 | 0.74 | POLB (0.41) | NPC1RAB9AL3MBTL1LMNATP53 | |
| SCHEMBL22372297 | 0.72 | HPGD (0.48) | NPC1RAB9ACYP1A2LMNAKMT2A | |
| SCHEMBL10245943 | 0.72 | KDM4E (0.49) | NPC1RAB9AL3MBTL1LMNAHIF1A | |
| SCHEMBL5223245 | 0.71 | L3MBTL1 (0.52) | L3MBTL1CYP1A2LMNAKMT2AMEN1 | |
| SCHEMBL1520108 | 0.71 | MMP13 (0.60) | L3MBTL1CYP1A2CYP2D6KMT2AGAA | |
| SCHEMBL3008643 | 0.71 | KDM4E (0.55) | L3MBTL1LMNASMN1; SMN2KDM4E | |
| SCHEMBL1437259 | 0.71 | CNR1 (0.41) | L3MBTL1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318375-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010009062-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 2010-01-21 | — | — | WO | disclosed |