Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.59 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18415459 | 0.83 | LMNA (0.66) | LMNAPLA2G1BATG4BHTTHPGD | |
| SCHEMBL6468546 | 0.83 | RAB9A (0.68) | LMNAPLA2G1BATG4BHTTHPGD | |
| SCHEMBL31294636 | 0.81 | MEN1 (0.73) | HPGDRAB9AALDH1A1POLBKMT2A | |
| SCHEMBL2553685 | 0.81 | HTT (0.65) | LMNAPLA2G1BATG4BHTTHPGD | |
| SCHEMBL1274911 | 0.80 | LMNA (0.68) | LMNAPLA2G1BATG4BHTTHPGD | |
| SCHEMBL2530016 | 0.79 | KMT2A (0.63) | LMNAPLA2G1BATG4BHTTHPGD | |
| SCHEMBL689542 | 0.79 | CYP2C19 (0.66) | LMNAPLA2G1BATG4BHTTHPGD | |
| SCHEMBL5318410 | 0.79 | LMNA (0.61) | LMNAPLA2G1BATG4BHTTHPGD | |
| SCHEMBL4963071 | 0.79 | LMNA (0.56) | LMNAPLA2G1BATG4BHTTHPGD | |
| SCHEMBL1423344 | 0.78 | GAA (0.59) | LMNAHPGDALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310775-B1 | 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES | Bayer Pharma AG (DE) | 2020-04-01 | — | — | EP | disclosed |
| US-10227299-B2 | 3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-03-12 | — | — | US | disclosed |
| US-20180155285-A1 | 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-06-07 | — | — | US | disclosed |
| EP-3310775-A1 | 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016202755-A1 | 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227299-B2 | 3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones | MYC, HCCS, MCL1 | LMNA 3607/4885PLA2G1B 3341/4885ATG4B 187/4885 |
| US-20180155285-A1 | 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES | HCCS, MCL1, MKI67 | LMNA 3608/4885PLA2G1B 3012/4885ATG4B 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.