Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20337484 | 0.88 | USP2 (0.37) | USP30USP2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL18320481 | 0.88 | USP2 (0.37) | USP30USP2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL31184416 | 0.88 | USP2 (0.37) | USP30USP2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29959213 | 0.88 | USP2 (0.37) | USP30USP2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL31336522 | 0.85 | USP2 (0.38) | USP30USP2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29366691 | 0.85 | USP2 (0.38) | USP30USP2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL31566827 | 0.81 | USP30 (0.41) | ESR2USP30USP2SMN1; SMN2NR1H2 | |
| SCHEMBL28900028 | 0.80 | — | — | |
| SCHEMBL30577842 | 0.77 | CHRM2 (0.35) | USP30USP2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4774218 | 0.76 | USP30 (0.43) | ESR2USP30USP2SMN1; SMN2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310774-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | Novartis AG (CH) | 2018-04-25 | — | — | EP | disclosed |
| EP-3310771-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | Novartis AG (CH) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016203405-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2016-12-22 | — | — | WO | disclosed |
| WO-2016203406-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2016-12-22 | — | — | WO | disclosed |