Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25187228 | 0.89 | CYP1A2 (0.55) | CYP1A2SMN1; SMN2ANPEPMEN1KMT2A | |
| SCHEMBL27356033 | 0.87 | SMN1; SMN2 (0.48) | PPARGCYP1A2SMN1; SMN2ANPEPPOLB | |
| SCHEMBL4992960 | 0.84 | CYP1A2 (0.66) | PPARGCYP1A2ANPEP | |
| SCHEMBL12333260 | 0.84 | SMN1; SMN2 (0.60) | PPARGSMN1; SMN2ANPEPMEN1KMT2A | |
| SCHEMBL7293687 | 0.81 | SMN1; SMN2 (0.50) | CYP1A2SMN1; SMN2ANPEPMEN1KMT2A | |
| SCHEMBL25346616 | 0.80 | SMN1; SMN2 (0.63) | PPARGSMN1; SMN2ANPEPMEN1KMT2A | |
| SCHEMBL1627443 | 0.79 | SMN1; SMN2 (0.54) | CYP1A2SMN1; SMN2ANPEPMEN1KMT2A | |
| SCHEMBL11081034 | 0.79 | APAF1 (0.54) | CYP1A2SMN1; SMN2ANPEPMEN1KMT2A | |
| SCHEMBL27929812 | 0.79 | APAF1 (0.54) | CYP1A2SMN1; SMN2ANPEPMEN1KMT2A | |
| SCHEMBL12450939 | 0.79 | APAF1 (0.54) | CYP1A2SMN1; SMN2ANPEPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318377-B1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH INC (US) | 2013-08-21 | — | — | EP | disclosed |
| US-20120165313-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8044078-B2 | Amino-alkyl amide derivatives as CCR3 receptor ligands | SANOFI-AVENTIS (FR) | 2011-10-25 | — | — | US | disclosed |
| EP-2318377-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-05-11 | — | — | EP | disclosed |
| US-20100069357-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-03-18 | — | — | US | disclosed |
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |
| US-4785003-A | N-disubstituted glycine and B-amino-propionic acid derivatives having anti-ulcer activity | BIOMEASURE, INC. (US) | 1988-11-15 | — | — | US | disclosed |
| US-4598067-A | Antiulcer compounds | BIOMEASURE, INC. (US) | 1986-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165313-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | MTOR, TYMS, DTYMK | PPARG 1862/4885CYP1A2 1791/4885SMN1; SMN2 1868/4885 |
| US-20100069357-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | MTOR, TYMS, DTYMK | PPARG 1862/4885CYP1A2 1791/4885SMN1; SMN2 1868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.