Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322866 | 0.92 | PDGFRB (0.47) | PDGFRBPDGFRAHRH3KCNH2ADRA1A | |
| SCHEMBL18322938 | 0.87 | CHRNB1 (0.43) | PDGFRBPDGFRAHRH3KCNH2ADRA1A | |
| SCHEMBL18322967 | 0.85 | PDGFRB (0.52) | PDGFRBPDGFRAHRH3KCNH2ADRA1A | |
| SCHEMBL18322896 | 0.85 | HRH3 (0.38) | PDGFRBPDGFRAHRH3KCNH2MAP4K1 | |
| SCHEMBL18322886 | 0.83 | TGFBR1 (0.44) | HRH3TGFBR1ACVR1 | |
| SCHEMBL18322937 | 0.80 | PRKCZ (0.41) | PDGFRBPDGFRAHRH3 | |
| SCHEMBL18319021 | 0.80 | PIK3CA (0.51) | PDGFRBPDGFRA | |
| SCHEMBL18318241 | 0.79 | PDGFRB (0.50) | PDGFRBPDGFRAHRH3ALDH1A1F2 | |
| SCHEMBL18322946 | 0.78 | HTR7 (0.37) | HRH3KCNH2ADRA1ACHEK2 | |
| SCHEMBL18322916 | 0.78 | GSK3B (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310441-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205633-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |