Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 6/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 5/20 | 0.41 |
| ▸ | CHUK | O15111 | 3/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322939 | 0.85 | GSK3B (0.43) | WNT1CLK2CLK3GSK3BDYRK1A | |
| SCHEMBL18322916 | 0.85 | GSK3B (0.45) | WNT1CLK2CLK3GSK3BDYRK1A | |
| SCHEMBL18322961 | 0.82 | GSK3B (0.43) | WNT1CLK2CLK3GSK3BDYRK1A | |
| SCHEMBL18322859 | 0.82 | ROCK1 (0.45) | ROCK1ROCK2AKT1HRH3 | |
| SCHEMBL18322880 | 0.82 | ROCK1 (0.43) | ROCK1HRH3 | |
| SCHEMBL18322904 | 0.81 | GSK3B (0.42) | GSK3BFASNHRH3 | |
| SCHEMBL18322871 | 0.81 | ROCK1 (0.42) | ROCK1ROCK2WNT1CLK2CLK3 | |
| SCHEMBL18322946 | 0.81 | HTR7 (0.37) | ROCK1ROCK2WNT1CLK2CLK3 | |
| SCHEMBL18322938 | 0.79 | CHRNB1 (0.43) | PRKCZDYRK1AFASNHRH3 | |
| SCHEMBL18322866 | 0.79 | PDGFRB (0.47) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310441-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205633-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |