Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KDM5A | P29375 | 3/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 7/20 | 0.32 |
| ▸ | TPMT | P51580 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323633 | 0.88 | BRD4 (0.38) | KDM4EBRD4ALDH1A1MEN1KMT2A | |
| SCHEMBL18323590 | 0.87 | KDM4E (0.39) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL15907125 | 0.83 | RARG (0.34) | KDM5AKDM4CKDM5BPLA2G2AMEN1 | |
| SCHEMBL18323638 | 0.81 | KDM4E (0.50) | KDM4EBRD4KMT2A | |
| SCHEMBL18323585 | 0.81 | KDM5A (0.41) | KDM4EKDM5AKDM4CKDM5BTPMT | |
| SCHEMBL18323697 | 0.75 | KDM4E (0.56) | KDM4EKDM5AKDM4CKDM5BBRD4 | |
| SCHEMBL18323694 | 0.73 | KDM4E (0.39) | KDM4EBRD4TPMTALDH1A1HSD17B10 | |
| SCHEMBL18323656 | 0.73 | SMN1; SMN2 (0.38) | KDM4EBRD4ALDH1A1 | |
| SCHEMBL18323577 | 0.72 | KDM4E (0.36) | KDM4EKDM5AKDM4CKDM5BBRD4 | |
| SCHEMBL10377918 | 0.72 | KDM4E (0.41) | KDM4EBRD4TPMTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |