Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323581 | 0.88 | KDM4E (0.34) | BRD4KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL18323621 | 0.86 | TSHR (0.44) | BRD4CHEK2KDM4ETSHRLMNA | |
| SCHEMBL18323590 | 0.86 | KDM4E (0.39) | KDM4ELMNAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL15907098 | 0.84 | CHEK2 (0.32) | IKBKBCHEK2TSHRKMT2AMEN1 | |
| SCHEMBL18323620 | 0.82 | BRD4 (0.39) | BRD4KDM4ETSHRLMNABPTF | |
| SCHEMBL18323638 | 0.80 | KDM4E (0.50) | BRD4KDM4EKMT2A | |
| SCHEMBL18323618 | 0.75 | KDM4E (0.55) | BRD4KDM4ETSHRLMNAKMT2A | |
| SCHEMBL18323675 | 0.73 | BRD4 (0.39) | BRD4KDM4ETSHRLMNABPTF | |
| SCHEMBL18323639 | 0.73 | BRD4 (0.40) | BRD4KDM4ELMNAKMT2AMKNK2 | |
| SCHEMBL18323673 | 0.72 | TSHR (0.43) | CHEK2KDM4ETSHRLMNABPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |