Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323626 | 0.92 | BRD4 (0.38) | BRD4KDM4EKMT2ATSHRLMNA | |
| SCHEMBL18323625 | 0.84 | POLB (0.34) | BRD4TSHR | |
| SCHEMBL18323589 | 0.83 | KDM4E (0.38) | BRD4KDM4EKMT2AALDH1A1GAA | |
| SCHEMBL15907093 | 0.82 | MEN1 (0.33) | KMT2ATSHR | |
| SCHEMBL18323675 | 0.82 | BRD4 (0.39) | BRD4KDM4EKMT2ATSHRLMNA | |
| SCHEMBL18323578 | 0.79 | KDM5A (0.41) | BRD4KDM4EALDH1A1 | |
| SCHEMBL18323618 | 0.79 | KDM4E (0.55) | BRD4KDM4EKMT2AGAATSHR | |
| SCHEMBL18323621 | 0.76 | TSHR (0.44) | BRD4KDM4EKMT2AALDH1A1TSHR | |
| SCHEMBL18323639 | 0.76 | BRD4 (0.40) | BRD4KDM4EKMT2ALMNA | |
| SCHEMBL18323592 | 0.76 | KDM5A (0.39) | BRD4KDM4EALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |