Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
| ▸ | BPTF | Q12830 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323577 | 0.87 | KDM4E (0.36) | BRD4KDM4EKMT2A | |
| SCHEMBL18323608 | 0.86 | CA12 (0.40) | BRD4KDM4ELMNAKMT2A | |
| SCHEMBL18323691 | 0.84 | MET (0.34) | LMNATSHRMETHTTNCOA1 | |
| SCHEMBL15907107 | 0.83 | MEN1 (0.32) | KMT2ATSHR | |
| SCHEMBL18323672 | 0.82 | BRD4 (0.40) | BRD4KDM4ELMNAKMT2ATSHR | |
| SCHEMBL18323626 | 0.80 | BRD4 (0.38) | BRD4KDM4ELMNAKMT2ATSHR | |
| SCHEMBL18323620 | 0.78 | BRD4 (0.39) | BRD4KDM4ELMNAKMT2ATSHR | |
| SCHEMBL18323632 | 0.77 | KDM4E (0.55) | BRD4KDM4E | |
| SCHEMBL18323618 | 0.77 | KDM4E (0.55) | BRD4KDM4ELMNAKMT2ATSHR | |
| SCHEMBL18323621 | 0.75 | TSHR (0.44) | BRD4KDM4ELMNAKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |