Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | BRD4 | O60885 | 8/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323697 | 0.84 | KDM4E (0.56) | KDM4EBRD4KMT2AGLATSHR | |
| SCHEMBL18323639 | 0.83 | BRD4 (0.40) | KDM4EBRD4LMNAPARP1KMT2A | |
| SCHEMBL18323696 | 0.81 | BRD4 (0.39) | KDM4EBRD4LMNAPARP1KMT2A | |
| SCHEMBL18323620 | 0.81 | BRD4 (0.39) | KDM4EBRD4LMNAPARP1KMT2A | |
| SCHEMBL15907124 | 0.81 | MEN1 (0.36) | KDM4EBRD4LMNAPARP1KMT2A | |
| SCHEMBL18323588 | 0.80 | KDM4E (0.51) | KDM4ELMNAKMT2AGAASMN1; SMN2 | |
| SCHEMBL18323619 | 0.79 | BRD4 (0.37) | KDM4EBRD4LMNAPARP1KMT2A | |
| SCHEMBL18323672 | 0.79 | BRD4 (0.40) | KDM4EBRD4LMNAKMT2ATSHR | |
| SCHEMBL18323628 | 0.79 | BRD4 (0.37) | KDM4EBRD4LMNAKMT2ATSHR | |
| SCHEMBL18323675 | 0.77 | BRD4 (0.39) | KDM4EBRD4LMNAKMT2APARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |