Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7516932 | 0.97 | TP53 (0.64) | HPGDUSP2TP53SMN1; SMN2HSD17B10 | |
| SCHEMBL9359712 | 0.88 | ALDH1A1 (0.57) | HPGDUSP2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9356310 | 0.84 | HPGD (0.60) | HPGDUSP2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL12381384 | 0.83 | L3MBTL1 (0.56) | HPGDTP53SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL14699972 | 0.80 | KMT2A (0.74) | HPGDTP53SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL10053023 | 0.79 | HPGD (0.75) | HPGDALDH1A1L3MBTL1NPC1DRD3 | |
| SCHEMBL7469360 | 0.79 | MRGPRX4 (0.71) | HPGDTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8983023 | 0.79 | SMN1; SMN2 (0.57) | HPGDSMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL29556803 | 0.79 | MRGPRX4 (0.71) | HPGDTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL16134867 | 0.78 | POLB (0.70) | HPGDTP53SMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416410-B1 | Piperaziniocephalosporins | SHIONOGI & CO (JP) | 1994-11-30 | — | — | EP | disclosed |
| US-5143910-A | PIPERAZINIOCEPHALOSPORINS | SHIONOGI & CO., LTD. (JP) | 1992-09-01 | — | — | US | disclosed |
| EP-0416410-A1 | Piperaziniocephalosporins | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1991-03-13 | — | — | EP | disclosed |