Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13860604 | 0.79 | KDM4E (0.42) | PTGS2PTGDR2SRCSMN1; SMN2KDM4E | |
| SCHEMBL13860502 | 0.76 | PTGS2 (0.38) | PTGS2PTGDR2SRCKMT2AMEN1 | |
| SCHEMBL18136497 | 0.71 | NSD3 (0.46) | PTGS2SRCSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL17326656 | 0.70 | HSD17B10 (0.59) | SMN1; SMN2CYP3A4CYP2C9CYP2C19KDM4E | |
| SCHEMBL18324220 | 0.70 | PDE1A (0.47) | ADORA1ADORA2APTGDR2NUDT1BRD4 | |
| SCHEMBL15657185 | 0.69 | NR1H2 (0.41) | PTGS2PTGDR2SRCCYP3A4CYP2C9 | |
| SCHEMBL19645481 | 0.68 | MEN1 (0.42) | PTGS2PTGDR2BRD4SRCSMN1; SMN2 | |
| SCHEMBL18129997 | 0.66 | SRC (0.44) | PTGS2SRCSMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL15656182 | 0.64 | RET (0.38) | ADORA1PTGS2PTGDR2SRCCYP3A4 | |
| SCHEMBL27476495 | 0.64 | BRD4 (0.39) | ADORA1NUDT1BRD4SRCCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2712358-B1 | PYRROLIDINYL UREA, PYRROLIDINYL THIOUREA AND PYRROLIDINYL GUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2016-12-21 | — | — | EP | disclosed |