Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18136497 | 0.84 | NSD3 (0.46) | MEN1KMT2APTGS2NPSR1ALDH1A1 | |
| SCHEMBL18134414 | 0.84 | ADORA3 (0.47) | MEN1KMT2ANPSR1ALDH1A1LMNA | |
| SCHEMBL18129997 | 0.82 | SRC (0.44) | MEN1KMT2APTGS2NPSR1ALDH1A1 | |
| SCHEMBL18134417 | 0.76 | BRD4 (0.60) | MEN1KMT2ANPSR1ALDH1A1LMNA | |
| SCHEMBL15716628 | 0.76 | MEN1 (0.38) | MEN1KMT2APTGS2NPSR1ALDH1A1 | |
| SCHEMBL13860604 | 0.70 | KDM4E (0.42) | MEN1KMT2APTGS2ALDH1A1LMNA | |
| SCHEMBL12859302 | 0.70 | PTGS2 (0.43) | PTGS2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL4219564 | 0.70 | PTGS2 (0.40) | MEN1KMT2APTGS2NPSR1ALDH1A1 | |
| SCHEMBL13860502 | 0.69 | PTGS2 (0.38) | MEN1KMT2APTGS2ALDH1A1SRC | |
| SCHEMBL17326656 | 0.69 | HSD17B10 (0.59) | KMT2ANPSR1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828360-B2 | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-11-28 | — | — | US | disclosed |