Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10244731 | 0.82 | — | — | |
| Water SCHEMBL28557869 | 0.80 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL14707175 | 0.79 | MEN1 (0.42) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL422199 | 0.78 | PRMT1 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL22282294 | 0.74 | LMNA (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL3478490 | 0.73 | — | — | |
| SCHEMBL464490 | 0.73 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL12446699 | 0.72 | — | — | |
| SCHEMBL872556 | 0.71 | CHRNB2 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL10828045 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951185-B1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC (US) | 2016-12-21 | — | — | EP | disclosed |