Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27752922 | 0.85 | KCNH2 (0.50) | HTR2AHRH1TRPM8KCNH2SIGMAR1 | |
| SCHEMBL11451801 | 0.85 | KCNH2 (0.50) | HTR2AHRH1TRPM8KCNH2SIGMAR1 | |
| Bromide SCHEMBL27753188 | 0.84 | KCNH2 (0.49) | HTR2AHRH1TRPM8KCNH2SIGMAR1 | |
| Bromide SCHEMBL27732806 | 0.84 | KCNH2 (0.49) | HTR2AHRH1TRPM8KCNH2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL27732854 | 0.84 | KCNH2 (0.49) | HTR2AHRH1TDP1TRPM8KCNH2 | |
| Hydrochloric Acid SCHEMBL27732840 | 0.84 | KCNH2 (0.49) | HTR2AHRH1TDP1TRPM8KCNH2 | |
| SCHEMBL12126358 | 0.83 | HTR2A (0.45) | HTR2AHRH1LMNATDP1AOC3 | |
| SCHEMBL28279550 | 0.82 | LMNA (0.43) | HTR2AHRH1LMNATDP1AOC3 | |
| SCHEMBL17772997 | 0.80 | L3MBTL1 (0.43) | HTR2AHRH1LMNATDP1TRPM8 | |
| SCHEMBL10513477 | 0.79 | HTR2A (0.47) | HTR2AHRH1LMNATDP1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3106463-A1 | SUBSTITUTED PYRAZOLO[1,5-]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-12-21 | — | — | EP | disclosed |