Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 8/20 | 0.37 |
| ▸ | BRD2 | P25440 | 7/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 7/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896791 | 0.91 | CYP3A4 (0.44) | CYP3A4CYP2C9ALDH1A1HTTBRD4 | |
| SCHEMBL16896910 | 0.81 | BRD4 (0.40) | CYP3A4CYP2C9BRD4BRD2BRD3 | |
| SCHEMBL18326385 | 0.74 | EZH2 (0.43) | CYP3A4CYP2C9BRD4BRD2BRD3 | |
| SCHEMBL16905852 | 0.71 | CYP3A4 (0.43) | CYP3A4CYP2C9HTTBRD4BRD2 | |
| SCHEMBL16896826 | 0.71 | MEN1 (0.43) | CYP3A4CYP2C9BRD4BRD2BRD3 | |
| SCHEMBL18326390 | 0.70 | THRB (0.36) | ALDH1A1HTTMAPTKDM4ELMNA | |
| SCHEMBL18326404 | 0.69 | BRD4 (0.44) | CYP3A4CYP2C9ALDH1A1BRD4BRD2 | |
| SCHEMBL18326405 | 0.68 | CYP3A4 (0.40) | CYP3A4CYP2C9HTTBRD4BRD2 | |
| SCHEMBL18326406 | 0.67 | BRD4 (0.40) | CYP3A4CYP2C9BRD4BRD2BRD3 | |
| SCHEMBL16896894 | 0.66 | GPR119 (0.42) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590118-B2 | Bicyclic heterocyclic derivatives as bromodomain inhibitors | ORION CORPORATION (FI) | 2020-03-17 | — | — | US | disclosed |
| US-20160368906-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2016-12-22 | — | — | US | disclosed |
| US-20160368906-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368906-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | BRD1, BRD2, BRD3 | CYP3A4 1942/4885CYP2C9 1528/4885ALDH1A1 2949/4885 |
| US-10590118-B2 | Bicyclic heterocyclic derivatives as bromodomain inhibitors | BRD1, BRD2, BRD3 | CYP3A4 1942/4885CYP2C9 1528/4885ALDH1A1 2949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.