SCHEMBL18329

SCHEMBL18329

[c]1ccc2ncccc2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.54
NPC1 O15118 4/20 0.47
POLB P06746 2/20 0.47
RAB9A P51151 2/20 0.47
MAPT P10636 5/20 0.44
HTT P42858 4/20 0.44
KDM4E B2RXH2 3/20 0.44
CASP1 P29466 2/20 0.44
TP53 P04637 2/20 0.44
HSP90AA1 P07900 2/20 0.44
TSHR P16473 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
ATM Q13315 2/20 0.44
HSP90AB1 P08238 1/20 0.44
HSD17B10 Q99714 1/20 0.44
CYP3A4 P08684 2/20 0.41
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
LMNA P02545 2/20 0.39
CASP7 P55210 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17830 0.83 ALDH1A1 (0.54) ALDH1A1NPC1POLBRAB9AMAPT
SCHEMBL5438885 0.80 NPC1 (0.54) ALDH1A1NPC1POLBRAB9AMAPT
SCHEMBL17511948 0.79 NPC1 (0.44) ALDH1A1NPC1POLBRAB9AMAPT
SCHEMBL17511958 0.79 NPC1 (0.44) ALDH1A1NPC1POLBRAB9AMAPT
Quinoline SCHEMBL405162 0.74 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9AMAPT
Quinoline SCHEMBL28512615 0.74 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9AMAPT
Quinoline SCHEMBL27615425 0.74 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9AMAPT
Quinoline SCHEMBL2790076 0.74 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9AMAPT
Quinoline SCHEMBL27258190 0.74 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9AMAPT
SCHEMBL452574 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 19911 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324804-A Aromatic phosphonate compound and synthesis method thereof 海南大学 2024-07-12 CN claimed
EP-4392032-A1 MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR FOR THE TREATMENT OR PREVENTION OF RENAL CYSTIC DISEASE AND CARDIORENAL SYNDROME Arena Pharmaceuticals, Inc. (US) 2024-07-03 EP claimed
US-20240201205-A1 METHOD FOR DETECTING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US claimed
US-20240197682-A1 METHOD FOR TREATING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US claimed
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US claimed
US-12011444-B2 N-substituted indole derivatives as PGE2 receptor modulators IDORSIA PHARMACEUTICALS LTD (CH) 2024-06-18 US claimed
US-20240190901-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-06-13 US claimed
CN-118084831-A Tetra-substituted furan compound and preparation method thereof 重庆大学 2024-05-28 CN claimed
US-11987588-B2 Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto ARENA PHARMACEUTICALS, INC. (US) 2024-05-21 US claimed
US-20240139182-A1 Certain Triazolopyridines and Triazolopyrazines, Compositions Thereof and Methods of Use Therefor HUTCHISON MEDIPHARMA LTD (CN) 2024-05-02 US claimed
US-4801595-A REDUCED CNS DEPRESSANT PROPERTIES JOHN WYETH & BROTHER LIMITED (GB) 1989-01-31 US claimed
EP-0296780-A2 Light-sensitive silver halide color photographic material containing novel cyan coupler KONICA CORPORATION (JP) 1988-12-28 EP claimed
CN-86107819-A Heterogeneous ring compound 1987-06-10 CN claimed
EP-0209337-A2 Adhesives Smith & McLaurin Ltd. (GB) 1987-01-21 EP claimed
US-4636506-A BACTERICIDES, STAPHYLOCOCCUS PFIZER, INC. (US) 1987-01-13 US claimed
EP-0005911-B1 ANALGESIC 6-ACYLAMINOTETRAHYDRO-1,3,5-TRIAZINE-2,4-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND PROCESS FOR THEIR MANUFACTURE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-02-17 EP claimed
US-4254122-A ANALGESICS, ANTIINFLAMMATORY AGENTS, ENZYME INHIBITORS OF PROSTAGLANDIN SYNTHETASE IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-03-03 US claimed
US-4198513-A ANTI-GOUT AND ANTI-HYPERURICEMIC AGENTS MERCK & CO., INC. (US) 1980-04-15 US claimed
EP-0005911-A1 Analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives, pharmaceutical compositions thereof, and process for their manufacture IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1979-12-12 EP claimed
US-4175956-A Electrophotosensitive materials for migration imaging processes EASTMAN KODAK COMPANY (US) 1979-11-27 US claimed