Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.52 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.48 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.48 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.94 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL2790076 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL27615425 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL27258190 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28512615 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL27879213 | 0.97 | ALDH1A1 (0.90) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL29087059 | 0.97 | ALDH1A1 (0.90) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28855560 | 0.97 | ALDH1A1 (0.90) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL29418238 | 0.97 | ALDH1A1 (0.90) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL27443844 | 0.97 | ALDH1A1 (0.90) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28139063 | 0.97 | ALDH1A1 (0.90) | ALDH1A1NPC1POLBRAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3253 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105198861-B | 6- acyl group -1,2,4- triazine -3,5- derovatives and herbicide | FMC公司 | 2019-11-22 | — | — | CN | claimed |
| CN-104507317-B | Composition comprising a biological control agent and a fungicide, use thereof, kit | 拜尔农作物科学股份公司 | 2019-11-15 | — | — | CN | claimed |
| CN-110461854-A | Process for preparing chiral 2, 3-dihydrothiazolo [3,2-A ] pyrimidin-4-ium compounds | BASF SE | 2019-11-15 | — | — | CN | claimed |
| CN-110461159-A | Fungicidal compositions | SYNGENTA PARTICIPATIONS AG | 2019-11-15 | — | — | CN | claimed |
| CN-104519742-B | Compositions comprising biological control agents and pesticides | 拜尔农作物科学股份公司 | 2019-10-25 | — | — | CN | claimed |
| CN-110367251-A | A kind of synergetic pesticide composition containing nopinene | 广西汇丰生物科技有限公司 | 2019-10-25 | — | — | CN | claimed |
| CN-110367252-A | A kind of synergetic pesticide composition containing p-cymene | 广西汇丰生物科技有限公司 | 2019-10-25 | — | — | CN | claimed |
| CN-110300522-A | For preventing and treating the composition that harmful microbe includes 1- (Phenoxy-pyridin base) -2- (1,2,4- triazol-1-yl)-alcohol derivative | 拜耳公司 | 2019-10-01 | — | — | CN | claimed |
| CN-110300521-A | FUNGICIDAL COMPOSITIONS | 先正达参股股份有限公司 | 2019-10-01 | — | — | CN | claimed |
| CN-110087466-A | ACTIVE COMPOUND COMBINATIONS | 拜耳作物科学股份公司 | 2019-08-02 | — | — | CN | claimed |
| US-7109130-B2 | Zeolite films for low k applications | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2006-09-19 | — | — | US | claimed |
| US-20050282401-A1 | Zeolite films for low k applications | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2005-12-22 | — | — | US | claimed |
| WO-2005109475-A2 | ZEOLITE FILMS FOR LOW K APPLICATIONS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2005-11-17 | — | — | WO | claimed |
| CN-1568703-A | Attapulgite-argentum nanometer composite antibiotic material and preparation method thereof | UNIV HEFEI TECHNOLOGY (CN) | 2005-01-26 | — | — | CN | claimed |
| CN-1386507-A | Compound antiparasitic medicine for fish or full-value feed containing antiparasitic medicine | WANG YUWAN (CN) | 2002-12-25 | — | — | CN | claimed |
| EP-0574655-B1 | Lubricating compositions containing aromatic amine derivatives of 2,5-dimercapto-1,3,4-thiadiazoles | VANDERBILT CO R T (US) | 1998-04-08 | — | — | EP | claimed |
| EP-0601266-B1 | Aromatic amine derivatives of 2,5-dimercapto-1,3,4-thiadiazoles | VANDERBILT CO R T (US) | 1996-06-26 | — | — | EP | claimed |
| US-5391756-A | Antiwear and antioxidant oil additives for lubricants | R. T. VANDERBILT COMPANY, INC. (US) | 1995-02-21 | — | — | US | claimed |
| EP-0601266-A1 | Aromatic amine derivatives of 2,5-dimercapto-1,3,4-thiadiazoles | R.T. VANDERBILT COMPANY, Inc. (US) | 1994-06-15 | — | — | EP | claimed |
| EP-0574655-A1 | Lubricating compositions containing aromatic amine derivatives of 2,5-dimercapto-1,3,4-thiadiazoles | R.T. VANDERBILT COMPANY, Inc. (US) | 1993-12-22 | — | — | EP | claimed |