Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 7/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 5/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | LAP3 | P28838 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30572343 | 1.00 | CAPN1 (0.42) | CAPN1CTSKCTSBTERTDPP4 | |
| SCHEMBL26548018 | 1.00 | CAPN1 (0.42) | CAPN1CTSKCTSBTERTDPP4 | |
| SCHEMBL14298969 | 0.94 | CAPN1 (0.39) | CAPN1CTSKCTSBTERTDPP4 | |
| SCHEMBL15381168 | 0.85 | PAX8 (0.40) | CTSKTERTDPP4DPP8DPP9 | |
| SCHEMBL24324147 | 0.85 | DPP4 (0.46) | CAPN1CTSKCTSBDPP4DPP8 | |
| SCHEMBL25571940 | 0.85 | DPP4 (0.46) | CAPN1CTSKCTSBDPP4DPP8 | |
| SCHEMBL5454396 | 0.85 | DPP4 (0.46) | CAPN1CTSKCTSBDPP4DPP8 | |
| SCHEMBL2740152 | 0.85 | CAPN1 (0.45) | CAPN1CTSKCTSBDPP4DPP8 | |
| SCHEMBL17305085 | 0.84 | CASP1 (0.40) | CTSC | |
| SCHEMBL8621285 | 0.81 | PAX8 (0.47) | CAPN1CTSKCTSBDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016205277-A1 | PD-L1 ANTAGONIST COMBINATION TREATMENTS | MERCK PATENT GMBH (DE) | 2016-12-22 | — | — | WO | disclosed |