Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.41 |
| ▸ | CBFB | Q13951 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12658168 | 1.00 | F2 (0.54) | F2PRSS1PRSS2PRSS3SMN1; SMN2 | |
| SCHEMBL1833219 | 1.00 | F2 (0.54) | F2PRSS1PRSS2PRSS3SMN1; SMN2 | |
| SCHEMBL1830250 | 0.87 | MAPK1 (0.46) | SMN1; SMN2MAPTKMT2ACA2KDM4E | |
| SCHEMBL12658062 | 0.87 | MAPK1 (0.46) | SMN1; SMN2MAPTKMT2ACA2KDM4E | |
| SCHEMBL1830247 | 0.87 | MAPK1 (0.46) | SMN1; SMN2MAPTKMT2ACA2KDM4E | |
| SCHEMBL1828515 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2ACA2KDM4EALDH1A1 | |
| SCHEMBL1828512 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2ACA2KDM4EALDH1A1 | |
| SCHEMBL13438569 | 0.79 | F2 (0.54) | F2PRSS1PRSS2PRSS3SMN1; SMN2 | |
| SCHEMBL1831727 | 0.79 | F2 (0.54) | F2PRSS1PRSS2PRSS3SMN1; SMN2 | |
| SCHEMBL1831724 | 0.79 | F2 (0.54) | F2PRSS1PRSS2PRSS3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320520-B1 | SULFONYLGUANIDINE | GRUENENTHAL GMBH (DE) | 2011-05-11 | — | — | EP | claimed |
| US-7671074-B2 | Sulfonylguanidine compounds and pharmaceutical uses thereof | GRUENENTHAL GMBH (DE) | 2010-03-02 | — | — | US | claimed |
| US-20080085900-A1 | SULFONYLGUANIDINE COMPOUNDS AND PHARMACEUTICAL USES THEREOF | GRUENENTHAL GMBH (DE) | 2008-04-10 | — | — | US | claimed |
| US-20030225084-A1 | Sulfonylguanidine compounds and pharmaceutical uses thereof | GRUENENTHAL GMBH (DE) | 2003-12-04 | — | — | US | claimed |
| US-7671074-B2 | Sulfonylguanidine compounds and pharmaceutical uses thereof | GRUENENTHAL GMBH (DE) | 2010-03-02 | — | — | US | disclosed |
| US-20080085900-A1 | SULFONYLGUANIDINE COMPOUNDS AND PHARMACEUTICAL USES THEREOF | GRUENENTHAL GMBH (DE) | 2008-04-10 | — | — | US | disclosed |
| US-20030225084-A1 | Sulfonylguanidine compounds and pharmaceutical uses thereof | GRUENENTHAL GMBH (DE) | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085900-A1 | SULFONYLGUANIDINE COMPOUNDS AND PHARMACEUTICAL USES THEREOF | CACNA1G, CACNA1I, CACNA1A | F2 2763/4885PRSS1 1446/4885PRSS2 1486/4885 |
| US-20030225084-A1 | Sulfonylguanidine compounds and pharmaceutical uses thereof | CACNA1G, CACNA1I, CACNA1A | F2 2763/4885PRSS1 1446/4885PRSS2 1486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.