Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21527055 | 1.00 | ALDH1A1 (0.35) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL21527078 | 0.69 | ICAM1 (0.32) | — | |
| SCHEMBL21527059 | 0.66 | NLRP3 (0.32) | — | |
| SCHEMBL1230234 | 0.66 | CYP19A1 (0.33) | MEN1KMT2AMITFATM | |
| SCHEMBL21526998 | 0.65 | NLRP3 (0.31) | — | |
| SCHEMBL1704641 | 0.64 | ALDH1A1 (0.51) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL14925980 | 0.64 | ALDH1A1 (0.51) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL3294572 | 0.64 | ALDH1A1 (0.51) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL13759915 | 0.62 | ALDH1A1 (0.34) | ALDH1A1 | |
| SCHEMBL18948659 | 0.62 | KDM4E (0.51) | ALDH1A1KDM4EMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10463644-B2 | Uses of sesquiterpene lactone compounds and their derivatives in drugs preparation | ACCENDATECH (CN) | 2019-11-05 | — | — | US | disclosed |
| US-20160367525-A1 | USES OF SESQUITERPENE LACTONE COMPOUNDS AND THEIR DERIVATIVES IN DRUGS PREPARATION | ACCENDATECH (CN) | 2016-12-22 | — | — | US | disclosed |
| US-20160367525-A1 | USES OF SESQUITERPENE LACTONE COMPOUNDS AND THEIR DERIVATIVES IN DRUGS PREPARATION | ACCENDATECH (CN) | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10463644-B2 | Uses of sesquiterpene lactone compounds and their derivatives in drugs preparation | MCL1, TNF, LSS | ALDH1A1 70/4885KDM4E 2200/4885MEN1 1063/4885 |
| US-20160367525-A1 | USES OF SESQUITERPENE LACTONE COMPOUNDS AND THEIR DERIVATIVES IN DRUGS PREPARATION | MCL1, TNF, LSS | ALDH1A1 70/4885KDM4E 2200/4885MEN1 1063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.