Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PDE8B | O95263 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 4/20 | 0.30 |
| ▸ | HTR2A | P28223 | 4/20 | 0.30 |
| ▸ | DRD3 | P35462 | 4/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20123968 | 0.88 | — | — | |
| SCHEMBL12081534 | 0.82 | SLC6A12 (0.39) | HPGDFEN1NAMPTBRD4PDE8B | |
| SCHEMBL2201489 | 0.82 | SLC6A12 (0.39) | HPGDFEN1NAMPTBRD4PDE8B | |
| SCHEMBL12080316 | 0.82 | SLC6A12 (0.39) | HPGDFEN1NAMPTBRD4PDE8B | |
| SCHEMBL14689835 | 0.80 | ALOX5 (0.34) | HPGDFEN1NAMPTPSEN1PSEN2 | |
| SCHEMBL20835098 | 0.80 | BRD4 (0.34) | HPGDFEN1NAMPTBRD4PDE8B | |
| SCHEMBL10549973 | 0.80 | HPGD (0.33) | HPGDFEN1NAMPTPSEN1PSEN2 | |
| SCHEMBL3651504 | 0.80 | ALOX5 (0.34) | HPGDFEN1NAMPTPSEN1PSEN2 | |
| SCHEMBL14689816 | 0.80 | ALOX5 (0.34) | HPGDFEN1NAMPTPSEN1PSEN2 | |
| SCHEMBL1192557 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016205202-A1 | TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF | Corsair Pharma, Inc. (US) | 2016-12-22 | — | — | WO | disclosed |