Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.69 |
| ▸ | FBP1 | P09467 | 3/20 | 0.69 |
| ▸ | GAK | O14976 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.64 |
| ▸ | BUB1 | O43683 | 2/20 | 0.64 |
| ▸ | STK10 | O94804 | 2/20 | 0.64 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.64 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.64 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.64 |
| ▸ | CARS1 | P49589 | 1/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.62 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7665701 | 0.99 | EGFR (0.67) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL29894409 | 0.85 | ABCG2 (0.76) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL183355 | 0.85 | ABCG2 (0.76) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL29484155 | 0.85 | EGFR (0.69) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL256396 | 0.85 | EGFR (0.69) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL28407487 | 0.85 | EGFR (0.69) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL2607975 | 0.85 | EGFR (0.72) | EGFRFBP1GAKALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3873473 | 0.84 | EGFR (0.67) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL1507464 | 0.82 | EGFR (0.70) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL1507562 | 0.82 | EGFR (0.67) | EGFRFBP1GAKALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907642-A1 | PHENYLAMINO-SUBSTITUTED TRICYCLIC DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | PFIZER INC. (US) | 1999-04-14 | — | — | EP | claimed |
| WO-1997049688-A1 | PHENYLAMINO-SUBSTITUTED TRICYCLIC DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | PFIZER INC. (US) | 1997-12-31 | — | — | WO | claimed |
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| US-6335344-B1 | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases | PFIZER INC. | 2002-01-01 | — | — | US | disclosed |
| EP-0907642-A1 | PHENYLAMINO-SUBSTITUTED TRICYCLIC DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | PFIZER INC. (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049688-A1 | PHENYLAMINO-SUBSTITUTED TRICYCLIC DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | PFIZER INC. (US) | 1997-12-31 | — | — | WO | disclosed |