Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trifluoroacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ODC1 | P11926 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3149138 | 0.88 | HRH4 (0.41) | TSHRALDH1A1HRH4HRH3ODC1 | |
| Trifluoroacetic Acid SCHEMBL10619788 | 0.88 | HRH4 (0.41) | TSHRALDH1A1HRH4HRH3ODC1 | |
| Trifluoroacetic Acid SCHEMBL4701422 | 0.87 | ODC1 (0.43) | TSHRALDH1A1HRH4HRH3ODC1 | |
| Trifluoroacetic Acid SCHEMBL11052838 | 0.85 | HRH4 (0.40) | TSHRHRH4HRH3ODC1LMNA | |
| Trifluoroacetic Acid SCHEMBL11404300 | 0.84 | ALDH1A1 (0.36) | TSHRALDH1A1SMN1; SMN2CA2THRB | |
| Trifluoroacetic Acid SCHEMBL11509703 | 0.84 | ALDH1A1 (0.36) | TSHRALDH1A1SMN1; SMN2CA2THRB | |
| Trifluoroacetic Acid SCHEMBL27638860 | 0.83 | GLRA1 (0.53) | TSHRALDH1A1HRH4HRH3ODC1 | |
| Trifluoroacetic Acid SCHEMBL3149196 | 0.82 | ODC1 (0.48) | TSHRALDH1A1HRH4HRH3ODC1 | |
| Trifluoroacetic Acid SCHEMBL10619767 | 0.82 | ODC1 (0.48) | TSHRALDH1A1HRH4HRH3ODC1 | |
| Trifluoroacetic Acid SCHEMBL6490887 | 0.82 | HRH4 (0.50) | TSHRALDH1A1HRH4HRH3ODC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3835383-B1 | ONE COMPONENT (1K) CURABLE ADHESIVE COMPOSITION | HENKEL AG & CO KGAA (DE) | 2023-04-12 | — | — | EP | claimed |
| EP-3835381-B1 | TWO COMPONENT (2K) CURABLE ADHESIVE COMPOSITION | HENKEL AG & CO KGAA (DE) | 2023-02-08 | — | — | EP | claimed |
| US-20220411673-A1 | ONE COMPONENT (1K) CURABLE ADHESIVE COMPOSITION | HENKEL AG & CO. KGAA (DE) | 2022-12-29 | — | — | US | claimed |
| US-20220389289-A1 | TWO COMPONENT (2K) CURABLE ADHESIVE COMPOSITION | HENKEL AG & CO KGAA (DE) | 2022-12-08 | — | — | US | claimed |
| WO-2021115771-A1 | ONE COMPONENT (1K) CURABLE ADHESIVE COMPOSITION | HENKEL AG & CO. KGAA (DE) | 2021-06-17 | — | — | WO | claimed |
| WO-2021115772-A1 | TWO COMPONENT (2K) CURABLE ADHESIVE COMPOSITION | HENKEL AG & CO. KGAA (DE) | 2021-06-17 | — | — | WO | claimed |
| EP-3835381-A1 | TWO COMPONENT (2K) CURABLE ADHESIVE COMPOSITION | Henkel AG & Co. KGaA (DE) | 2021-06-16 | — | — | EP | claimed |
| EP-3835383-A1 | ONE COMPONENT (1K) CURABLE ADHESIVE COMPOSITION | Henkel AG & Co. KGaA (DE) | 2021-06-16 | — | — | EP | claimed |
| EP-1926737-B1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-03-15 | — | — | EP | claimed |
| CN-101263145-B | 4-amino-thieno [3,2-C ] pyridine-7-carboxylic acid derivatives | HOFFMANN LA ROCHE | 2015-02-25 | — | — | CN | claimed |
| CN-104277051-A | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | HOFFMANN LA ROCHE | 2015-01-14 | — | — | CN | claimed |
| EP-2038288-B1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-11-24 | — | — | EP | claimed |
| EP-2038288-A1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | claimed |
| EP-1926737-A1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-04 | — | — | EP | claimed |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | CHEN YI | 2008-01-10 | — | — | US | claimed |
| WO-2008000697-A1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENO[3,2]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | claimed |
| WO-2007031428-A1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-22 | — | — | WO | claimed |
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BARTKOVITZ DAVID J | 2007-03-15 | — | — | US | claimed |
| EP-3835381-B1 | TWO COMPONENT (2K) CURABLE ADHESIVE COMPOSITION | HENKEL AG & CO KGAA (DE) | 2023-02-08 | — | — | EP | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BRAF, RAF1, MAP3K7 | TSHR 2559/4885ALDH1A1 933/4885HRH4 1845/4885 |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | UQCRB, UQCRC2, AURKB | TSHR 1051/4885ALDH1A1 379/4885HRH4 3349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.