Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | QDPR | P09417 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1771697 | 0.85 | PDK4 (0.48) | BTKJAK1 | |
| SCHEMBL1834588 | 0.81 | MAPT (0.39) | MAPTQDPRPOLBLMNAMEN1 | |
| SCHEMBL27964122 | 0.80 | KDM4E (0.34) | MAPTALDH1A1ALOX15TSHR | |
| SCHEMBL18186201 | 0.74 | MAPT (0.40) | MAPTQDPRPOLBLMNAMEN1 | |
| SCHEMBL17048186 | 0.72 | SLC6A4 (0.40) | MAPTPOLBLMNAMEN1ALDH1A1 | |
| SCHEMBL17048184 | 0.72 | SLC6A4 (0.40) | MAPTPOLBLMNAMEN1ALDH1A1 | |
| SCHEMBL1937547 | 0.72 | GABRP (0.46) | BTKMAPTQDPRALDH1A1SMN1; SMN2 | |
| SCHEMBL21714595 | 0.71 | MAPT (0.44) | MAPTQDPRPOLBLMNAMEN1 | |
| SCHEMBL28504627 | 0.71 | MAPT (0.40) | MAPTQDPRPOLBLMNAMEN1 | |
| SCHEMBL28365728 | 0.71 | MAPT (0.40) | MAPTQDPRPOLBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318392-A2 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010002655-A2 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-01-07 | — | — | WO | disclosed |