Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SCD | O00767 | 2/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | QDPR | P09417 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1771022 | 0.83 | PDK4 (0.51) | CNR1 | |
| SCHEMBL1833900 | 0.81 | BTK (0.34) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL18186201 | 0.76 | MAPT (0.40) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL1937547 | 0.74 | GABRP (0.46) | MAPTALDH1A1QDPRLIMK1LIMK2 | |
| SCHEMBL21714595 | 0.74 | MAPT (0.44) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL28899975 | 0.74 | SCD (0.37) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL23034993 | 0.74 | SCD (0.62) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL28365728 | 0.74 | MAPT (0.40) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL28504627 | 0.74 | MAPT (0.40) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL22324861 | 0.73 | FASN (0.43) | MAPTLMNAMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318392-A2 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010002655-A2 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-01-07 | — | — | WO | disclosed |